- Addresses the unique needs of menopausal and post-menopausal skins
- The more mature skin has special requirements. As we age the skin becomes thinner and more fragile. Cellular senescence causes cells to stop replicating themselves through the process of mitosis, resulting in a buildup of senescent cells in the body. The body’s ability to clear these cells decreases with age, and that triggers cellular degradation over a period of time. The importance of cellular senescence to the aging process has long been suspected – it denotes a stable and long-term loss of proliferative capacity, despite continued viability and metabolic activity. Latest research demonstrates that these cells play a significant role in skin aging. By delaying senescence, via telomere stabilization, Rejuvenate can extend cell life-span by as much as one-third. The skin regains its density, firmness, elasticity and smoothness.
- Another consequence of senescence is a defective skin surface, which leads to moisture loss and dry skin as skin barrier renewal and repair slows down. The skin’s Natural Moisturising Factors (NMF) consist mainly of lactate and pyroglutaminate components. These are easily washed off by soaps and other sufactants, resulting in the premature desquamation of the epithelial cells and a loss of suppleness. Rejuvenate contains both sodium lactate and sodium PCA, as major NMF factors, as well as urea, glycine, phospholipids, niacinamide, ceramides, sphingosines and cholesterol. These ingredients give Rejuvenate it’s biomimetic properties – they replenish the skins own protective lipid barrier, induce the production of new lipids and activate the skins natural water management function.
- With age, loss of subcutaneous fat weakens the skin’s resistance to external mechanical pressure and causes physiological changes such as thinning of the skin, hollow cheeks, wrinkles and a less sculpted oval shape (see diagram below). Rejuvenate contains a novel variant of Isoleucine, an essential amino acid known for its ability to support tissue repair and act as a natural alternative for lipofilling, by working on multiple layers of the skin to fill wrinkles internally and plump hollow cheeks. It stimulates keratinocyte differentation for a refreshed appearance (calcium like effect), reinforces the 3D network and fibroblast activity for a fuller and firmer dermis and stimulates and protects adipocytes, leading to an increase in skin volume.
- The niacinamide in Rejuvenate has an occlusive effect, without being greasy. A published study found that niacinamide was more effective than petrolatum (a common occlusive ingredient in moisturisers) in reducing water loss from the skin and in increasing its moisture levels. Niacinamide is also non-comedogenic (pore clogging) and is a potent anti-aging ingredient in its own right. Decrease in skin elasticity, loss of firmness and the appearance of lines and wrinkles are the visible signs of ageing skin. The main factor in skin ageing is the gradual loss of collagen and elastin in the skin. Without any help or protection, the collagen level in your skin is depleted at a rate of 1.5% every year, starting in your mid 20s. By the time you celebrate your 40th birthday, your skin may have lost 30% of its collagen. Niacinamide increases the production of collagen by 54% and elastin by 20%. A clinical study in 50 women showed that niacinamide significantly improved the appearance of ageing skin. N-acetyl-glucosamine (NAG) & Niacinamide, together, confer multiple skin benefits, including pigmentation reduction*, decrease in sallowness and increased skin elasticity and tone. They also synergistically promote natural desquamation of the skin, without the need for exfoliation.
- The phospholipids in Rejuvenate restore the barrier function of the skin, protecting it from harmful substances and bacteria. Natural phospholipids contain relatively high amounts of linoleic acid, which plays an important role in the skins own synthesis of Ceramide 1, a lipid that is important for intact barrier function.
- The ribose in Rejuvenate is a fundamental building block of the ATP molecule – the most important source of cell energy. To function efficiently, cells must keep ATP at a maximum level. Each cell contains a reserve of ATP but there is a limited capacity to store it and only small amounts are available at any time. In healthy cells, under normal conditions, the ATP reserve is maintained at a constant level. However, during stressful conditions, the energy needs of the cell are higher than recycling capacity and ATP levels fall dramatically. The energising action of ribose on fibroblasts stimulates the synthesis of all the structural proteins (mainly collagen, elastin and fibronectin).
- Temperature and humidity responsive lipid bilayer. This bilayer interacts with the lipid bilayers within the stratum corneum to reinforce the skin’s natural barrier. It responds to varying temperatures and humidities to help balance and maintain the skin’s optimum hydration levels – conditions which change daily as we are exposed to seasonal variations and climate controlled environments.
*Extended exposure to Ultraviolet (UV) rays triggers the overproduction of Melanin (a pigment that gives your skin a colour), the main cause of hyperpigmentation, also known as age spots or dark spots. Niacinamide doesn’t reduce the production of melanin but it helps prevent Melanin reaching the top layers of the skin, by about 68%. In an 8 week clinical-trial, niacinamide was shown to reduce the appearance of dark spots by more than 25% and even out skin tone.