Fade Brightening Serum

Helps, at many levels, to block the biochemical cascade that leads to pigmentation issues. This is achieved by blocking the production and activity of tyrosinase, the enzyme that leads to the production of melanin.

This version of Fade Serum does not contain Ascorbic Acid and is a skin-friendlier serum than Fade Plus Serum. It is recommended for those who may experience breakout issues from using a strong vitamin C serum (such as Fade Plus) and need a more moisturising product with other skin benefits. It contains:

• Phosopholipids and biomimetic moisturising factors
• Hyaluronic Acid
• Xyloglucans
• Oligopeptide-68
• 4% Alpha Arbutin and
• 4% Kojic Acid.

Oligopeptide-68 is a complex combination of TGF-ß agonist peptide that inhibits Microphtalmia-associated transcription factor (MITF). MITF is a major transcriptional regulator of melanogenic enzymes, tyrosinase, TRP-1 and TRP-2. This peptide induces significant skin brightening and is shown to have a higher activity than Arbutin and vitamin C.

Hyaluronic acid (HA) is a non-sulfated glycosaminoglycan (GAG), naturally distributed in human body. Hyaluronic acid is the major component of the extracellular matrix. It is found in high quantity in the skin, where it is produced by fibroblasts and keratinocytes. One of its main functions is to hold water in the intercellular matrix of the connective tissue. This water-binding capacity contributes significantly to the elasticity of the skin. Hyaluronic acid plays the role of water pump, maintaining elasticity by acting as a water reservoir. Hyaluronic acid is also involved in tissue repair. While it is abundant in extracellular matrices, it also contributes to tissue hydrodynamics, movement and proliferation of cells, and it participates in a number of cell surface receptor interactions, notably those including its primary receptor, CD44. EGF Serum contains a high molecular weight HA which is able to hold 1000 times its own weight in water, to deliver immediate intensive hydration to the surface layers of the skin, for an instant smoothing and firming effect.

The presence of skin-identical phospholipids and biomimetic moisturising factors in Fade Serum helps repair and hydrate the skin’s natural barrier and replenish depleted NMF (Natural Moisturising Factors), namely: Sodium Lactate, Sodium PCA, Glycine, Fructose, Urea, Niacinamide, Inositol and Lactic Acid.

Xyloglucans (or Tamarindus indica polysaccharides), endowed with remarkable filming and hydrating properties, enhances the serum’s hydration activity by stimulating the production of filligrin, a protein crucial in maintaining skin hydration.  Research shows that cutaneous hydration immediately improved by >59% at 30 minutes, and, over a longer period (30 days) improved skin hydration by >35%, providing a strong moisturizing effect, both short and long term. Xyloglucans also inhibit senescence-related β-galactosidase, which is typically overexpressed in aging keratinocytes, especially those exposed to UV radiation damage and oxidative stress. Research also shows that xyloglucans improved overall skin elasticity by >19%, and decreased skin roughness by >21%, providing a visible anti-wrinkle effect. Furthermore, the combination of xyloglucans and hyaluronic acid stimulates the production of the anti-inflammatory cytokine, IL-10.

Alternative Serum:

Fade Plus version (here) contains 8% L-Ascorbic Acid, 4% Kojic Acid, 4% Alpha Arbutin & Glutathione. It is intended for those who wish to add vitamin C to their skin brightening regimen.