Which Topical Vitamins Work?

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26 Sep

Comments (2)

    1. There are two chemical reactions that occur when you mix niacinamide and ascorbic acid:

      The first occurs when you mix niacinamide with any acid, or base, and that’s the conversion of niacinamide to niacin. This takes a long time and is (or should be) of concern for manufacturers that are using niacinamide in either acidic or basic products. Niacinamide likes to be at pH~6. Niacin has the side effect of activating Langerhan cells in the skin which leads to the release of prostaglandins and dilation of the blood vessels causing your skin to flush and tingle. This flushing and tingling is temporary, but can be uncomfortable and potentially problematic for someone with inflammatory acne or erythema.

      The second concern is the formation of a complex between niacinamide and ascorbic acid. This complex, called niacinamide ascorbate, no longer benefits the skin, and may produce hydrogen peroxide, leading to skin cell death. This reaction is, however, pH dependent and reversible.

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